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Pathogenesis of Persistent Human Virus Infections of Global Significance

具有全球意义的持续人类病毒感染的发病机制

基本信息

批准号：
nhmrc : 358399
负责人：
A/Pr Barry Slobedman
金额：
$ 438.18万
依托单位：
The University of Sydney
依托单位国家：
澳大利亚
项目类别：
Programs
财政年份：
2005
资助国家：
澳大利亚
起止时间：
2005-01-01 至 2009-12-31
项目状态：
已结题

来源：
https://researchdata.edu.au/pathogenesis-persistent-human-global-significance/94832
关键词：
Pathogenesis Persistent Human Virus Infections

项目摘要

The study will investigate why humans cannot eradicate particular viruses (HIV-AIDS, cytomegalovirus and herpes simplex virus), the long term effects of these viruses and ways to improve control. Current treatments can only partly suppress the levels of these viruses, because they persist in certain parts of the body called reservoirs, only to resurge later causing disease. Thus, the overall aim of the research program is to discover the mechanisms by which these viruses are able to successfully persist within reservoirs in the human body. The research program brings together a group of 6 leading scientists and clinicians located at 3 sites in 2 Australian cities. The team is comprised of experts in the study of HIV-AIDS, cytomegalovirus and herpes simplex virus who will combine their knowledge and expertise to speed up the process of research on these viruses that are of major health importance. Studies will also utilise a number of cutting edge technologies that now make it possible to much more rapidly and precisely determine how viruses cause disease. Advances in our understanding of how viruses persist may form the basis for treatments aimed at controlling persistent infections and the serious diseases caused by these viruses.

这项研究将调查为什么人类不能根除特定的病毒（艾滋病毒-艾滋病，巨细胞病毒和单纯疱疹病毒），这些病毒的长期影响和改善控制的方法。目前的治疗方法只能部分抑制这些病毒的水平，因为它们在身体的某些部位（称为水库）持续存在，只是为了在以后重新引起疾病。因此，研究计划的总体目标是发现这些病毒能够成功地在人体内的水库中持续存在的机制。该研究项目汇集了6位领先的科学家和临床医生，分布在澳大利亚2个城市的3个地点。该小组由研究艾滋病毒/艾滋病、巨细胞病毒和单纯疱疹病毒的专家组成，他们将联合收割机结合他们的知识和专长，加快对这些对健康具有重大意义的病毒的研究进程。研究还将利用许多尖端技术，这些技术现在可以更快、更精确地确定病毒如何引起疾病。我们对病毒如何持续存在的理解的进步可能会成为旨在控制持续感染和这些病毒引起的严重疾病的治疗方法的基础。