BIOMEDICAL RESEARCH SUPPORT

请求提供资金，以帮助购买一台高场核磁共振仪。 由七（7）个主要用户组使用的核磁共振（NMR）光谱仪 代表四个（4） 部门 研究主题的核心将由 购买本仪器是大分子结构表征 通过各种高分辨率NMR光谱技术。 大多数 待表征的系统中的一个是生物活性寡肽 和蛋白质，以及抗肿瘤药物与DNA的结合。 核磁共振技术提供的探测这种结构的机会， 复杂性是独一无二的，因此这项研究的意义在于， 这些研究将提供有关模式的基本信息， 这些生物分子的作用。

Funds are requested to aid in the purchase of a high-field nuclear magnetic resonance (NMR) spectrometer to be used by a user group of seven (7) major principals representing four (4) departments. Central to the theme of the research that will be coordinated by the purchase of this instrument is macromolecular structural characterization by a variety of high resolution NMR spectroscopy techniques. The majority of the systems to be characterised are biologically active oligopeptides and proteins with the addition of the binding of antitumor drugs to DNA. The opportunity offered by the NMR technique to probe structures of this complexity is unique and hence the significance of this research is that these studies will give fundamental information concerning the mode of action of these biomolecules.