RETROVIRAL ACTIVITY IN LYMPHOCYTES OF PATIENTS WITH SCHIZOPHRENIA

精神分裂症患者淋巴细胞中的逆转录病毒活性

• 批准号: 3900982
• 负责人: A FEENSTRA
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3900982
• 关键词: RNA directed DNA polymerase; Retroviridae disease; human T cell lymphotropic virus type 1; human T cell lymphotropic virus type 2; human immunodeficiency virus 1; human tissue; lymphocyte; mental disorder diagnosis; mental health epidemiology; nervous system disorder diagnosis; neurotropic virus; schizophrenia; tissue /cell culture; viral rescue; virus protein

Evidence that schizophrenia may involve infection by a virus (or viruses) has been indirect. The evidence includes the phenomenology of schizophrenia (insofar as it may be mimicked by some viral encephalitides), epidemiological factors (including a predominance among patients with late winter/early spring births, a north-south gradient, and occasional clustering of cases), and indirect laboratory evidence (gliosis in some neuropathological studies, spinal fluid protein abnormalities, and abnormalities in cell-mediated immunity). The discovery of the human retroviruses (HTLV-1, HTLV-11 and HIV, now also known to affect the central nervous system) and the development of new techniques in human retrovirology made it possible to investigate the role of this class of viruses in the etiology of schizophrenia. Cultures of peripheral lymphocytes of patients with chronic schizophrenia were established and tested for the retrovirus-specific enzyme reverse transcriptase.

精神分裂症可能与病毒感染有关的证据 都是间接的。证据包括 精神分裂症(可能被某些病毒性脑炎模仿)， 流行病学因素(包括在晚期患者中占主导地位 冬季/早春出生，南北梯度，偶尔 病例聚集性)和间接实验室证据(某些情况下的胶质细胞增多症 神经病理学研究，脊髓液蛋白质异常，以及 细胞免疫功能异常)。 人类逆转录病毒(HTLV-1，HTLV-11和HIV)的发现，现在也 已知会影响中枢神经系统)和新的 人类逆转录病毒学的技术使研究其作用成为可能。 这类病毒在精神分裂症病因学中的作用。 慢性精神分裂症患者外周血淋巴细胞的培养 被建立并检测逆转录病毒特异性酶逆转 转录酶。