RETROVIRAL ACTIVITY IN LYMPHOCYTES OF PATIENTS WITH SCHIZOPHRENIA

精神分裂症可能涉及病毒（或病毒）感染的证据 是间接的。 证据包括以下现象 精神分裂症（在某种程度上，它可能被某些病毒性脑炎模仿）， 流行病学因素（包括晚期 冬季/早春出生，南北梯度，偶尔 病例聚集）和间接实验室证据（一些病例中的神经胶质增生 神经病理学研究，脊髓液蛋白异常，以及 细胞介导的免疫异常）。 人类逆转录病毒（HTLV-1、HTLV-11和HIV，现在也 已知影响中枢神经系统）和新的 人类逆转录病毒学的技术使得研究 这类病毒在精神分裂症病因学中的作用。 慢性精神分裂症患者外周血淋巴细胞的培养 建立并测试逆转录病毒特异性酶逆转录酶， 录酶

Evidence that schizophrenia may involve infection by a virus (or viruses) has been indirect. The evidence includes the phenomenology of schizophrenia (insofar as it may be mimicked by some viral encephalitides), epidemiological factors (including a predominance among patients with late winter/early spring births, a north-south gradient, and occasional clustering of cases), and indirect laboratory evidence (gliosis in some neuropathological studies, spinal fluid protein abnormalities, and abnormalities in cell-mediated immunity). The discovery of the human retroviruses (HTLV-1, HTLV-11 and HIV, now also known to affect the central nervous system) and the development of new techniques in human retrovirology made it possible to investigate the role of this class of viruses in the etiology of schizophrenia. Cultures of peripheral lymphocytes of patients with chronic schizophrenia were established and tested for the retrovirus-specific enzyme reverse transcriptase.