RETROVIRAL ACTIVITY IN LYMPHOCYTES OF PATIENTS WITH SCHIZOPHRENIA

精神分裂症患者淋巴细胞中的逆转录病毒活性

• 批准号: 3921984
• 负责人: A FEENSTRA
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3921984
• 关键词: RNA directed DNA polymerase; Retroviridae disease; human T cell lymphotropic virus type 1; human T cell lymphotropic virus type 2; human immunodeficiency virus 1; human tissue; lymphocyte; mental disorder diagnosis; mental health epidemiology; nervous system disorder diagnosis; neurotropic virus; schizophrenia; tissue /cell culture; viral rescue; virus protein

Evidence that schizophrenia may involve infection by a virus (or viruses) has been indirect. The evidence includes the phenomenology of schizophrenia (insofar as it may be mimicked by some viral encephalitides), epidemiological factors (including a predominance among patients with late winter/early spring births, a north-south gradient, and occasional clustering of cases), and indirect laboratory evidence (gliosis in some neuropathological studies, spinal fluid protein abnormalities, and abnormalities in cell-mediated immunity.) The discovery of the human retroviruses (HTLV-I, HTLV-II and HIV, now also known to affect the central nervous system) and the development of new techniques in human retrovirology made it possible to investigate the role of this class of viruses in the etiology of schizophrenia. Cultures of peripheral lymphocytes of patients with chronic schizophrenia were established and tested for the retrovirus- specific enzyme reverse transcriptase.

有证据表明精神分裂症可能与病毒（或病毒）感染有关