EFFECTS OF SURGERY FOR HYPERTROPHIC CARDIOMYOPATHY ON EXERCISE HEMODYNAMICS
肥厚型心肌病手术对运动血流动力学的影响
基本信息
- 批准号:3899262
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Surgery for obstructive hypertrophic cardiomyopathy (septal
myotomy/myectomy or mitral valve replacement) improves symptoms in many,
but not all patients with hypertrophic cardiomyopathy. To assess which
hemodynamic changes before and following surgery best correlate with
exercise benefit following surgery, 14 patients with hypertrophic
cardiomyopathy underwent treadmill exercise testing (Bruce protocol) with
measurement of maximum oxygen consumption before and 6 months following
surgery. The post-operative exercise study demonstrated improved exercise
duration but with only a marginal improvement in maximum oxygen
consumption. The improvement in maximum oxygen consumption following
surgery compared to the preoperative study correlated directly with the
magnitude of reduction in left ventricular outflow gradient and left
ventricular end-diastolic pressure. The 5 patients with no improvement in
maximum oxygen consumption, including 2 with greater than 50 mmHg gradient
reduction, had less than 5 mmhg reduction in left ventricular end-diastolic
pressure. Seven of the 9 patients with increased post-operative maximum
oxygen consumption had a gradient reduction greater than or equal to 65
mmhg; the 2 with lesser gradient reduction had greater than 8 mmhg
reduction in left ventricular end-diastolic pressure. Thus, benefit in
exercise capacity following surgery may be determined as much by the
reduction in the left ventricular filling pressures as by the magnitude of
gradient reduction following surgery.
梗阻性肥厚型心肌病(间隔型)的手术治疗
肌切开术/肌切除术或二尖瓣置换术)改善了许多患者的症状,
但不是所有的肥厚型心肌病患者。评估哪些
手术前后的血流动力学变化与
手术后的运动益处,14例肥厚型
心肌病患者进行了平板运动试验(布鲁斯方案),
术前和术后6个月最大耗氧量测量
手术术后运动研究表明,
持续时间,但最大氧含量仅略有改善
消费最大耗氧量的改善
与术前研究相比,手术与
左心室流出道梯度和左心室
心室舒张末期压5例无改善的患者,
最大耗氧量,包括2例梯度大于50 mmHg的患者
降低,左心室舒张末期降低小于5 mmHg
压力术后最大值增加的9例患者中有7例
耗氧量的梯度降低大于或等于65
mmHg; 2例梯度减小较小的患者的血压大于8 mmHg
左心室舒张末期压降低。因此,受益于
手术后的运动能力可能取决于
左心室充盈压降低幅度为
手术后梯度降低。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('R O CANNON', 18)}}的其他基金
EFFECT OF SURGICAL RELIEF OF OBSTRUCTION IN HYPERTROPHIC CARDIOMYOPATHY
手术缓解肥厚型心肌病梗阻的效果
- 批准号:
4694686 - 财政年份:
- 资助金额:
-- - 项目类别:
DETRIMENTAL EFFECT OF ERGONOVINE IN HYPERTROPHIC CARDIOMYOPATHY
麦角新碱对肥厚性心肌病的不利影响
- 批准号:
4694671 - 财政年份:
- 资助金额:
-- - 项目类别:
ABNORMAL ESOPHAGEAL MOTILITY IN PATIENTS WITH LIMITED CORONARY FLOW RESERVE
冠状动脉血流储备有限患者的食管运动异常
- 批准号:
3966721 - 财政年份:
- 资助金额:
-- - 项目类别:
ABNORMAL BRONCHIAL AIRWAY FUNCTION IN PATIENTS WITH MICROVASCULAR ANGINA
微血管心绞痛患者支气管气道功能异常
- 批准号:
3920210 - 财政年份:
- 资助金额:
-- - 项目类别:
EFFECT OF LIDOFLAZINE ON EXERCISE TOLERANCE IN MICROVASCULAR ANGINA
利多嗪对微血管心绞痛运动耐量的影响
- 批准号:
3942959 - 财政年份:
- 资助金额:
-- - 项目类别:
EFFECT OF SURGICAL RELIEF OF OBSTRUCTION IN HYPERTROPHIC CARDIOMYOPATHY
手术缓解肥厚型心肌病梗阻的效果
- 批准号:
3942929 - 财政年份:
- 资助金额:
-- - 项目类别:
CORONARY FLOW RESERVE AND ABNORMAL LEFT VENTRICULAR RESPONSE TO EXERCISE
冠状动脉血流储备和左心室运动反应异常
- 批准号:
3843398 - 财政年份:
- 资助金额:
-- - 项目类别: