Delayed phase of remote ischemic preconditioning: clinical application and the role of kallikrein-kinin pathway.

远程缺血预适应的延迟期：临床应用和激肽释放酶-激肽途径的作用。

• 批准号: nhmrc : 557507
• 负责人: Prof Igor Konstantinov
• 金额: $ 10.62万
• 依托单位: Sir Charles Gairdner Hospital
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/delayed-phase-remote-kinin-pathway/81858
• 关键词: Delayed; phase; remote; ischemic; preconditioning

Brief episodes of interruption of blood flow to the arm or leg provide strong protection against prolonged interruption of blood flow to a target organ (e.g., heart or lung). This is known as remote ischemic preconditioning (RIPC). The strongest protection occurs 24 hours after blood flow interruption to the limb and may be mediated by a humoral cascade known as kallikrein-kinin. RIPC may provide protection against heart attack and stroke.

手臂或腿部血流短暂中断可提供强有力的保护，防止目标器官（例如心脏或肺）血流长期中断。这称为远程缺血预适应（RIPC）。最强的保护作用发生在肢体血流中断后 24 小时，并且可能由称为激肽释放酶-激肽的体液级联介导。 RIPC 可以预防心脏病和中风。