Dendritic cells in innate immunity and their potential clinical manipulation

先天免疫中的树突状细胞及其潜在的临床操作

• 批准号: nhmrc : 1003741
• 负责人: A/Pr Meredith O'Keeffe
• 金额: $ 29.6万
• 依托单位: Macfarlane Burnet Institute for Medical Research and Public Health
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dendritic-cells-innate-clinical-manipulation/108964
• 关键词: Dendritic; cells; innate; immunity; their

Dendritic cells (DC) are rare cells that are crucial in response to infection and surveillance of damaged tissues. We aim to understand the tools that are expressed by DC that allow them to sense pathogens and the functions of different DC types once a pathogen has been detected. The ultimate aim is to be able to understand and harness the functions of different DC so that we may directly target them upon demand to aid in the course of infection or potentially as tumour therapy.

树突状细胞（DC）是一种罕见的细胞，在应对感染和监测受损组织中至关重要。我们的目标是了解DC表达的工具，这些工具使它们能够感知病原体，以及一旦检测到病原体，不同DC类型的功能。最终目标是能够理解和利用不同DC的功能，以便我们可以根据需要直接靶向它们，以帮助感染过程或潜在的肿瘤治疗。