How does genetic variation for Trig affect autoimmune responses mediated by toll-like receptors?

Trig 的遗传变异如何影响 Toll 样受体介导的自身免疫反应？

• 批准号: nhmrc : 1029231
• 负责人: A/Pr Meredith O'Keeffe
• 金额: $ 44.75万
• 依托单位: St. Vincent's Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/does-genetic-variation-like-receptors/110677
• 关键词: How; does; genetic; variation; Trig

Juvenile diabetes is an autoimmune disease that affects more than 120,000 Australians. We have recently discovered a novel gene, named Trig, in a genetic study of mice that develop juvenile diabetes similar to children. This research proposal aims to determine the function of Trig in the immune system and how it contributes to the development of autoimmune diseases, such as juvenile diabetes.

青少年糖尿病是一种自身免疫性疾病，影响着超过12万澳大利亚人。我们最近发现了一种新的基因，名为TRIG，在一项对患青少年糖尿病的小鼠的遗传研究中，这种小鼠与儿童相似。这项研究计划旨在确定TRIG在免疫系统中的功能，以及它如何促进自身免疫性疾病的发展，如青少年糖尿病。