Exploring the innate immune system of bone marrow

探索骨髓的先天免疫系统

• 批准号: nhmrc : 1077633
• 负责人: A/Pr Meredith O'Keeffe
• 金额: $ 42.58万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/exploring-innate-immune-bone-marrow/518523
• 关键词: Exploring; innate; immune; system; bone

My work focuses on cells of the immune system that act as sentinels on the lookout for invading pathogens and danger. These cells are called dendritic cells. I am particularly interested in understanding how these cells function within the bone marrow environment and how they may sense viral infection or cancerous cells within this tissue. We aim to understand their function in specific diseases including Lupus and in pre-leukemia conditions, and also in infectious and parasitic diseases.

我的工作重点是免疫系统的细胞，它们充当哨兵，监视入侵的病原体和危险。这些细胞被称为树突细胞。我特别感兴趣的是了解这些细胞如何在骨髓环境中发挥作用，以及它们如何感知该组织中的病毒感染或癌细胞。我们的目标是了解它们在特定疾病中的功能，包括狼疮和白血病前状态，以及传染病和寄生虫病。