Genomic and functional analyses of a novel gene implicated in type 1 diabetes

与 1 型糖尿病相关的新基因的基因组和功能分析

• 批准号: nhmrc : 575552
• 负责人: A/Pr Meredith O'Keeffe
• 金额: $ 48.84万
• 依托单位: St. Vincent's Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/genomic-functional-analyses-1-diabetes/78367
• 关键词: Genomic; functional; analyses; novel; gene

We have recently discovered a novel gene that contributes to the development of juvenile diabetes. Unfortunately, very little is known about the function of this gene. To better understand how this gene affects the immune system and contributes to disease, we have generated a unique mouse strain that has a dysfunctional copy of this gene. These mice will enable us to characterise this gene and potentially establish a new area of research in diabetes prevention.

我们最近发现了一种有助于青少年糖尿病发展的新基因。不幸的是，人们对这个基因的功能知之甚少。为了更好地了解该基因如何影响免疫系统并导致疾病，我们培育了一种独特的小鼠品系，该品系具有该基因的功能失调副本。这些小鼠将使我们能够表征该基因，并有可能建立糖尿病预防的新研究领域。