NMR FACILITY FOR BIOMEDICAL STUDIES

在美国国立卫生研究院和美国国家科学基金会的联合赞助下， 在非持久模式下操作并产生140.9千高斯的场， 已被证明能产生足够稳定和均匀的磁场， 允许在600 MHz下观察高分辨率质子磁共振。 的 螺线管已被纳入一个常规的工作光谱仪， 目前已充分利用。 它主要用于质子，偶尔用于31 p 共振频率242 MHz。 其他的原子核也很少。 与 新的FT控制台正在进行中。 我们建议将该光谱仪作为 国家设施。 我们将为科学家提供核磁共振波谱服务， 包括那些从事健康相关研究的人：我们将执行 与同事合作研究解决方案的结构和功能， 生物活性肽;我们将进行核心研究，旨在提高 高场光谱仪的性能和多功能性以及新的 NMR的应用;我们将提供NMR理论和应用方面的培训， 学生和科学家--设施的使用者。

Under joint NIH-NSF sponsorship, a niobium-tin tape superconducting solenoid operating in nonpersistent mode and generating a field of 140.9 kilogauss has been demonstrated to produce fields of sufficient stability and homogeneity to permit observation of high resolution proton magnetic resonance at 600 MHz. The solenoid has been incorporated into a routine working spectrometer, and is currently fully utilized. It is used mostly for proton and occasionally for 31p resonance at 242 MHz. Few other nuclei are also available. Interfacing with a new FT console is underway. We propose to operate this spectrometer as a national facility. We will provide NMR spectroscopy service to scientists, including those engaged in health-related research: we will perform collaborative research with colleagues on the solution structure and function of bioactive peptides; we will perform core research aimed at improving the performance and versatility of the high-field spectrometer as well as on new applications of NMR; we will provide training in NMR theory and application to students and scientist--users of the facility.