TRANSVERSE NOE IN BIOMACROMOLECULES

目前正在开发最佳方法， 动态核Overhauser效应在结构和 生物大分子及其与小分子复合物的构象 和离子。 计算系统影响的数学方法 已经开发了许多自旋，这些方法将用于解释数据 在生物聚合物中的自旋扩散与质子间的距离和几何形状。 例如，将对生物感兴趣的各种系统进行测量 溶菌酶、α-胰凝乳蛋白酶、neurophysin、缓激肽和短杆菌肽S。

Optimum methods are being developed for the measurement and exploitation of dynamic nuclear Overhauser effects in the study of the structure and conformation of biomacromolecules and of their complexes with small molecules and ions. Mathematical methods for the calculation of effects in systems of many spins have been developed and these methods will be used to interpret data on spin diffusion in biopolymers with interproton distances and geometries. Measurements will be made on diverse systems of biological interest, for example lysozyme, alpha-chymotrypsin, neurophysin, Bradykinin, and gramicidin S.