NMR FACILITY FOR BIOMEDICAL STUDIES

在NIH-NSF的联合赞助下，一种Nb-TiN带状超导螺线管 在非持久模式下工作并产生140.9千古斯场 已经证明可以产生足够稳定和均匀的场来 允许在600兆赫观察高分辨率质子磁共振。这个 螺线管已被集成到常规工作光谱仪中，并且是 目前已全部用完。它主要用于质子，偶尔用于31便士。 共振频率为242兆赫。几乎没有其他原子核也是可用的。与 新的英国《金融时报》游戏机正在进行中。我们建议将这台光谱仪作为一种 国家设施。我们将为科学家提供核磁共振波谱服务， 包括那些从事健康相关研究的人：我们将执行 与同事合作研究解决方案的结构和功能 生物活性多肽；我们将进行核心研究，旨在改善 高场光谱仪的性能和通用性以及新的 核磁共振的应用；我们将提供核磁共振理论和应用方面的培训 学生和科学家--该设施的用户。

Under joint NIH-NSF sponsorship, a niobium-tin tape superconducting solenoid operating in nonpersistent mode and generating a field of 140.9 kilogauss has been demonstrated to produce fields of sufficient stability and homogeneity to permit observation of high resolution proton magnetic resonance at 600 MHz. The solenoid has been incorporated into a routine working spectrometer, and is currently fully utilized. It is used mostly for proton and occasionally for 31p resonance at 242 MHz. Few other nuclei are also available. Interfacing with a new FT console is underway. We propose to operate this spectrometer as a national facility. We will provide NMR spectroscopy service to scientists, including those engaged in health-related research: we will perform collaborative research with colleagues on the solution structure and function of bioactive peptides; we will perform core research aimed at improving the performance and versatility of the high-field spectrometer as well as on new applications of NMR; we will provide training in NMR theory and application to students and scientist--users of the facility.