Dengue host-cell signalling interactions: novel insights and interventions

登革热宿主细胞信号相互作用：新见解和干预措施

• 批准号: nhmrc : GNT1133360
• 负责人: Dr Sarah Garner
• 金额: $ 12.47万
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dengue-host-cell-insights-interventions/1347895
• 关键词: Dengue; host; cell; signalling; interactions

Dengue is a virus transmitted by mosquitoes that occurs in many tropical and subtropical regions. Approximately 40% of the world's population is at risk of this infection. Sometimes it can be mild but it can lead to severe illness and death especially with second infections. The body produces a response that over-reacts to the virus in these severe infections. The project aims to understand why the body does this and what parts of the immune system are affected using a model in mice.

登革热是一种通过蚊子传播的病毒，在许多热带和亚热带地区发生。世界上大约40%的人口面临这种感染的风险。有时它可能是轻微的，但可能会导致严重的疾病和死亡，特别是在二次感染的情况下。在这些严重的感染中，人体会产生对病毒的过度反应。该项目旨在通过小鼠的模型来了解人体为什么会这样做，以及免疫系统的哪些部分会受到影响。