DETERMINATION OF PRESSURE PATTERNS OF INJECTED CHEMOTHERAPEUTIC DRUGS

注射化疗药物压力模式的测定

• 批准号: 3937351
• 负责人: R CORSEY
• 金额: --
• 依托单位: DIVISION OF RESEARCH SERVICES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3937351
• 关键词: antineoplastics; drug administration routes; dyes; human subject; human tissue; injection /infusion; neoplasm /cancer chemotherapy; neoplasm /cancer pharmacology; pharmacokinetics

Studies of intraneoplastic injection of chemotherapeutic agents have shown an advantage for injection over intravenous or intraperitoneal administration. Intratumor injections are usually characterized by specifying the depth of needle penetration or merely indicating injections are subcutaneous. This study will explore the affect of varying injection pressure from bolus injection over a short time period to easily assimilated injection over a half hour or more. Various injection orifice structures will also be explored through the use of tumor models and dye injection.

肿瘤内注射化疗药物的研究 已经显示出注射优于静脉注射或 腹膜内给药。 瘤内注射通常 其特征在于指定针穿透深度，或 仅仅表明注射是皮下的。 本研究将 探索从大剂量开始改变注射压力的影响 在短时间内注射，以易于吸收注射 超过半小时或更长时间。 各种喷孔结构 也将通过使用肿瘤模型和染料进行探索 注射