THE USE OF FACIAL COOLING TO IMPROVE THE CONDITION OF MENTALLY DEPRESSED PATIENTS

使用面部冷却来改善精神抑郁患者的状况

• 批准号: 3937350
• 负责人: R CORSEY
• 金额: --
• 依托单位: DIVISION OF RESEARCH SERVICES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3937350
• 关键词: antidepressants; body temperature; brain; face; induced hypothermia; sleep deprivation

Patients with unipolar or bipolar affective disorder (depression) have been shown to have abnormally high nighttime temperatures. We hypothesize that elevated body temperature may be responsible for several alterations in depression such as reduced thyropin secretion. Procedures such as selective rapid eye movement (REM) sleep, total sleep deprivation, and administration of drugs such as tricyclic antidepressants appear to reduce brain temperature. We believe the antidepressant effects of these agents are related to their capacity to reduce brain temperature. Further, direct or indirect cooling of the brain might have antidepressant effects. We will test our hypothesis by cooling the face, which will cool the brain through countercurrent heat exchange with venous blood.

患有单相或双相情感障碍（抑郁症）的患者 已被证明夜间温度异常高。 我们推测体温升高可能是造成这种情况的原因 对于抑郁症的一些改变，例如甲状腺素减少 分泌。 选择性快速眼动 (REM) 等手术 睡眠、完全睡眠剥夺以及服用药物，例如 因为三环类抗抑郁药似乎可以降低大脑温度。 我们相信这些药物的抗抑郁作用是相关的 其降低大脑温度的能力。 此外，直接或 大脑的间接冷却可能具有抗抑郁作用。 我们将通过冷却脸部来检验我们的假设，脸部会变凉 大脑通过与静脉血逆流进行热交换。