PATHOPHYSIOLOGY OF CACHEXIA IN SARCOMA PATIENTS

这项研究旨在探索代谢需求的变化， 给病人带来的痛苦。 因为软组织肉瘤已经被证明 是代谢活跃的肿瘤，NCI正在治疗大量的 本研究仅限于四肢和躯干肉瘤患者， 肉瘤患者。 特别令人感兴趣的是： 1.是否有任何改变，在静息能量消耗，由于 肿瘤的存在？ 2.在恶病质发作之前，体细胞质量是否有任何改变？ 以前的研究仅限于重病患者或少数患者 病人。 本研究将试图进一步了解 隐性恶病质的病理生理学在临床上变得明显之前。 患者和志愿者将在年龄、性别和身体方面相匹配 表面积

This study is designed to explore alterations in metabolic demand which sarcomas imposed on patients. Since soft-tissue sarcomas have been shown to be metabolically active tumors and NCI is treating a large number of patients with extremity and truncal sarcomas this study will be limited to sarcoma patients. Of particular interest is the followin: 1. Is there any alteration in resting energy expenditure due to the presence of the tumor? 2. Is there any alteration in body cell mass prior to the onset of cachexia? Previous studies have been limited to very sick patients or small numbers of patients. This study will attempt to further our understanding of the pathophysiology of covert cachexia before it becomes clinically evident. Patients and volunteers will be matched with respect to age, sex, and body surface area.