EXOGENOUS INSULIN TO TREAT ANORECTIC WEIGHT LOSING CANCER PATIENTS

体重减轻是癌症患者的常见问题，影响他们的 生活质量和他们对治疗的反应能力。全胃肠外 营养一直未能扭转身体衰竭的现象 肿瘤学家质疑其在癌症治疗中的有效性 有耐心的。另一方面，胰岛素已被证明可以改善食物的摄入量， 无刺激消瘦状态大鼠的氮平衡和体重 肿瘤生长。胰岛素治疗也被证明可以增加身体细胞。 质量，动物的基本结构成分。在老鼠的研究中， 这一改进提高了肿瘤切除后的存活率。 这项研究将评估20名丢失的患者和至少10%的正常患者 体重，活组织检查证实患有癌症，处于厌食状态。这个 患者还必须有一个功能正常的胃肠道。这个 将调查以下问题。 1.小剂量外源性胰岛素能改善体重、细胞质量、食物吗 厌食症患者的摄入量、氮平衡和身体分解代谢 癌症？ 2.外源性胰岛素可以在不发育的情况下完成上述任务吗 血糖水平低到危险的地步？ 全身计数器将被用来测量每个人的K40水平 有耐心的。这一测量结果与人体细胞质量直接相关。休息 能量消耗将被确定，代谢厨房将被 用于平衡研究。

Weight loss is a common problem in patients with cancer, affecting their quality of life and their ability to respond to therapy. Total parenteral nutrition has not been able to reverse the body depletion phenomenon to the point where oncologist question the efficacy of its use in the cancer patient. On the other hand, insulin has been shown to improve food intake, nitrogen balance and body weight in wasting-state rats without stimulating tumor growth. Insulin treatment has also been shown to increase body cell mass, the fundamental structural component of animals. In rat studies, this improvement has led to improved survival following tumor resection. This study will evaluate 20 patients who have lost and least 10% of normal body weight, have biopsy proven cancer and are in an anorectic state. The patients also must have a functioning gastro-intestinal tract. The following questions will be investigated. 1. Can low-dose exogenous insulin improve body weight, cell mass, food intake, nitrogen balance and body catabolism of an anorectic patient with cancer? 2. Can exogenous insulin accomplish the above without developing dangerously low blood sugar levels? A whole body counter will be used to measure the K40 level of each patient. This measurement relates directly to the body cell mass. Resting energy expenditure will be determined and the metabolic kitchen will be utilized for a balance study.