DNA binding ligands for Auger therapy and receptor imaging

用于俄歇疗法和受体成像的 DNA 结合配体

• 批准号: nhmrc : 566559
• 负责人: Dr Tom Karagiannis
• 金额: $ 39.31万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dna-binding-ligands-receptor-imaging/76928
• 关键词: DNA; binding; ligands; Auger; therapy

Our aim is to develop new technologies for very specific cancer radiotherapy and diagnostic imaging. The system involves the use of a protein linked to a radioactive DNA binding drug. The radioactivity we use has a very small range -a few millionths of a millimetre- allowing us to selectively kill cancer cells with minimal harm to healthy tissue. For diagnosis we use smaller amounts of radiation to obtain a clear image of the areas and extent of disease, which facilitates appropriate treatment.

我们的目标是为非常特定的癌症放射治疗和诊断成像开发新技术。该系统涉及使用与放射性DNA结合药物连接的蛋白质。我们使用的放射性范围很小--几百万分之一毫米--使我们能够选择性地杀死癌细胞，对健康组织的伤害最小。对于诊断，我们使用较少量的辐射来获得疾病区域和程度的清晰图像，这有助于适当的治疗。