DNA barcoding of pathogenic fungi as the basis for the development of novel standardized diagnostic tools

病原真菌 DNA 条形码作为开发新型标准化诊断工具的基础

• 批准号: nhmrc : 1031952
• 负责人: A/Pr David Ellis
• 金额: $ 37.37万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dna-barcoding-pathogenic-diagnostic-tools/110833
• 关键词: DNA; barcoding; pathogenic; fungi; basis

Fungal infections are increasing and have major health impacts, with a high economic burden. Timely initiation of therapy is the key to improve patient outcomes. However, reliable identification tools for fungal pathogens are lacking. We will use comparative genome analysis to develop unique fungal signatures (DNA barcodes) and establish an online database to allow for rapid identification for diagnosis in the clinical setting and as a quarantine tool for border protection.

真菌感染正在增加，对健康造成重大影响，并带来沉重的经济负担。及时开始治疗是改善患者结局的关键。然而，缺乏可靠的真菌病原体鉴定工具。我们将使用比较基因组分析来开发独特的真菌特征（DNA条形码），并建立一个在线数据库，以便在临床环境中快速识别诊断，并作为边境保护的检疫工具。