FUNCTIONAL CONSEQUENCES OF EXPERIMENTAL NERVE LESIONS

实验性神经损伤的功能后果

• 批准号: 3944738
• 负责人: L DEMEDINACELLI
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3944738
• 关键词: brain mapping; chordate locomotion; nervous system regeneration; neuromuscular system; neurosurgery; peripheral nervous system; trauma

Crush lesions were made on sciatic nerves of rats. We examined the influence on recovery of the time elapsed between successive injuries and of location and number of damaged sites. The results were assessed over a post-operative period of 2.5 months by studying tracks obtained from walking rats. This study demonstrated the central role of basal lamina tube lesions in nerve injuries. In contrast, neither injury to the tissue of the nerve (Schwann cells), nor to the neurite itself influenced the functional outcome.

在大鼠坐骨神经上造成挤压损伤。 我们研究 连续两次手术之间的时间间隔对恢复的影响 受伤情况以及受损地点和数量。 结果 在术后2.5个月内进行了评估， 研究老鼠行走的轨迹 本研究 显示了基底板管病变的中心作用， 神经损伤 相反，对组织的损伤 神经（许旺细胞），也不影响神经突本身， 功能性成果。