POST-TRAUMATIC AUTOIMMUNE REACTION IN PERIPHERAL NERVE

周围神经的创伤后自身免疫反应

• 批准号: 3944739
• 负责人: L DEMEDINACELLI
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3944739
• 关键词: autoimmune disorder; neurosurgery; peripheral nervous system; trauma; wound healing

This study was conducted to show whether local autoimmune reactions can be observed after injury to the sciatic nerve in the rat. Furthermore, we attempted to correlate the intensity of the immunological reaction with the severity of nerve damage, the type of surgical treatment and the degree of functional recovery. A direct influence of autoimmunization was found. Its effect on functional recovery was moderate but constant.

这项研究的目的是为了证明局部自身免疫反应是否可以 在大鼠坐骨神经损伤后观察。 而且我们 试图将免疫反应的强度与 神经损伤的严重程度，手术治疗的类型和程度 功能恢复 发现自身免疫的直接影响。 其对功能恢复的影响是中等的，但恒定的。