FUNCTIONAL CONSEQUENCES OF EXPERIMENTAL NERVE LESIONS

实验性神经损伤的功能后果

• 批准号: 3968559
• 负责人: L DEMEDINACELLI
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3968559
• 关键词: chordate locomotion; denervation; model design /development; nervous system regeneration; neuromuscular system; neurosurgery; peripheral nervous system; trauma

Crush lesions were made on sciatic nerves of rats. We examined the influence on recovery of the time elapsed between successive injuries and of location and number of damaged sites. The results were assessed over a post-operative period of 2.5 months by studying tracks obtained from walking rats. This study demonstrated the capital role of basal lamina tube lesions in nerve injuries. In contrast, neither injury to the tissue of the nerve (Schwann cells), nor to the neurite itself influenced the functional outcome.

在大鼠坐骨神经上造成挤压损伤。 我们研究了 连续受伤之间的时间间隔对恢复的影响， 受损地点的位置和数量。 结果是在一个 术后2.5个月，通过研究从 会走路的老鼠 本研究证实了基膜的资本作用 神经损伤中的管损伤。 相比之下，组织损伤 的神经（许旺细胞），也没有对神经突本身的影响， 功能性成果。