Neurotransmitter signalling to two types of oligodendrocyte precursor cell in remyelination

髓鞘再生过程中向两种类型少突胶质细胞前体细胞发出的神经递质信号传导

基本信息

  • 批准号:
    G0701476/1
  • 负责人:
  • 金额:
    $ 61.21万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2009
  • 资助国家:
    英国
  • 起止时间:
    2009 至 无数据
  • 项目状态:
    已结题

项目摘要

For nerve fibres in the brain and spinal cord (the central nervous system, or CNS) to work properly, and enable us to feel, move, talk, see, think etc., they need to be covered by a sheath called myelin. In many neurological diseases myelin is lost and nerve fibres cannot conduct impulses properly, and may even die. Just as a skin wound can heal, myelin injuries can be healed spontaneously by stem cells present in the CNS. However, this repair process, called remyelination, often fails. Scientists are therefore studying how CNS stem cells can be encouraged to heal myelin injury more efficiently. In this project we will determine the role of two distinct CNS stem cells that we have recently identified in remyelination.When myelin is first produced in the developing brain the process is influenced by small molecules released from neurons, called neurotransmitters. However, it is unknown whether these neurotransmitters can influence remyelination. In this project we will study how remyelination by one or both types of stem cell is regulated by neurotransmitters. The results of this project will help in devising new remyelination therapies.
为了使大脑和脊髓(中枢神经系统,或CNS)中的神经纤维正常工作,使我们能够感觉,移动,说话,看,思考等,它们需要被一种叫做髓磷脂的鞘所覆盖。在许多神经系统疾病中,髓鞘丢失,神经纤维不能正常传导冲动,甚至可能死亡。就像皮肤伤口可以愈合一样,髓鞘损伤可以通过CNS中的干细胞自发愈合。然而,这种修复过程,称为髓鞘再生,往往失败。因此,科学家们正在研究如何鼓励CNS干细胞更有效地治愈髓鞘损伤。在这个项目中,我们将确定我们最近发现的两种不同的CNS干细胞在髓鞘再生中的作用。当髓鞘在发育中的大脑中首次产生时,该过程受到神经元释放的小分子(称为神经递质)的影响。然而,这些神经递质是否能影响髓鞘再生尚不清楚。在这个项目中,我们将研究神经递质如何调节一种或两种类型的干细胞的髓鞘再生。该项目的结果将有助于设计新的髓鞘再生疗法。

项目成果

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Ragnhildur Karadottir其他文献

Ragnhildur Karadottir的其他文献

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{{ truncateString('Ragnhildur Karadottir', 18)}}的其他基金

Functional implications of focal white matter lesions on neuronal circuits
局灶性白质病变对神经元回路的功能影响
  • 批准号:
    MR/Y014537/1
  • 财政年份:
    2024
  • 资助金额:
    $ 61.21万
  • 项目类别:
    Research Grant

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