Control of inflammation via the phosphorylation of tristetraprolin (TTP)

通过三四脯氨酸 (TTP) 磷酸化控制炎症

• 批准号: G0800207/2
• 负责人: Andrew Clark
• 金额: $ 17.7万
• 依托单位: University of Birmingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0800207%2F2
• 关键词: Control; inflammation; via; phosphorylation; tristetraprolin

Inflammation is normally a short-lived and beneficial response to infection or injury. However, in diseases like rheumatoid arthritis, inflammation persists in the absence of infection or injury, causing pain, disfunction and disfigurement. It is possible that persistent inflammation is due to the failure of resolution mechanisms, which would normally help to terminate an inflammatory response. In this project we are exploring the idea of stimulating or reactivating one of the body s natural inflammatory off-switches in order to treat chronic inflammatory diseases.

炎症通常是对感染或损伤的一种短暂而有益的反应。然而，在类风湿性关节炎等疾病中，炎症在没有感染或损伤的情况下持续存在，导致疼痛、功能障碍和毁容。持续性炎症可能是由于消退机制的失败所致，而消解机制通常有助于终止炎症反应。在这个项目中，我们正在探索刺激或重新激活S体内的一个自然炎症开关的想法，以治疗慢性炎症性疾病。