Genome-Wide Diversity In Village Dogs: Unvcovering The History Of Dog Domestication, The Genetics Of Natural Dog Populations, & Consequences Of Artificial Selection In Breed D

乡村狗的全基因组多样性：揭示狗驯化的历史，自然狗种群的遗传学，

• 批准号: 0948510
• 负责人: Andrew Clark
• 金额: $ 29.64万
• 依托单位: Cornell Univ - State: AWDS MADE PRIOR MAY 2010
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-15 至 2011-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0948510&HistoricalAwards=false
• 关键词: Genome; Wide; Diversity; Village; Dogs

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).Dogs descended from Eurasian gray wolves, but where and how this process occurred is poorly understood. Much genetic research has focused on breed dogs, but the diverse populations of semi-feral "village" dogs are likely an important key for understanding dog domestication. In this project, samples will be collected and analyzed for village dogs across Eurasia and compared to samples from breed dogs and wolves. Genotyping will be done on high-throughput (60,000 marker) arrays yielding unprecedented resolution of the dog genome, but only a partial picture of genetic diversity since these markers consist largely of variants found from the boxer and poodle genomes. Therefore, sequencing a subset of village dogs and wolves will be done to detect novel variation in these groups and determine how much biased marker ascertainment affects genetic inference from these arrays.As high-throughput genomic tools are developed for more and more organisms, tremendous research opportunities exist for studying related populations and species. Developing methods of genetic inference robust to ascertainment bias is crucial for utilizing these tools. This study will likely to challenge current theories of dog origins and develop village dogs into a useful system for the study of domestication, speciation, behavior and morphology.

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。狗是欧亚灰狼的后代，但这一过程在哪里以及如何发生的知之甚少。 许多遗传学研究都集中在品种狗上，但半野生“村庄”狗的多样性可能是理解狗驯化的重要关键。 在这个项目中，将收集和分析欧亚大陆村庄狗的样本，并与品种狗和狼的样本进行比较。 基因分型将在高通量（60，000个标记）阵列上进行，从而获得狗基因组的前所未有的分辨率，但只有遗传多样性的部分图片，因为这些标记主要由从拳击手和贵宾犬基因组中发现的变体组成。 因此，测序的一个子集的村庄狗和狼将完成检测新的变化，在这些群体，并确定有多少偏见的标记确定影响遗传推断从这些arrays.As高通量基因组工具的开发越来越多的生物体，巨大的研究机会存在研究相关的人口和物种。 开发对确定偏差具有鲁棒性的遗传推断方法对于利用这些工具至关重要。 这项研究可能会挑战现有的狗起源理论，并将乡村狗发展成为一个有用的系统，用于研究驯化，物种形成，行为和形态。