The Paediatric-Onset Inflammatory Bowel Disease Cohort and Treatment Study (PICTS)

儿科发病炎症性肠病队列和治疗研究 (PICTS)

• 批准号: G0800675/1
• 负责人: David Wilson
• 金额: $ 103.87万
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0800675%2F1
• 关键词: Paediatric; Onset; Inflammatory; Bowel; Disease

Inflammatory bowel disease (IBD) is a common problem in children and teenagers, with significant embarrassing symptoms, effects on growth and development, and interference with school progress, family and social life. There have been few successful research trials of therapies in childhood IBD, so we draw conclusions from studies in adults with IBD, where the issues can be different. Throughout Scotland, many children and teenagers (more than 450) have already joined our research study into the causes (in terms of genetic makeup and triggers in the environment) of IBD. This group is called a cohort, and our studies have been very successful in scientific terms to date. Although we have studied all potentially important genes that may have a role in the cause of IBD, none have been shown to have a major role ? the responsible genetic causes have yet to be found! We are increasing the numbers of Scottish children and young people in the cohort, which will help identify more potential genetic and environmental causes. We also wish to perform trials of therapies which will answer key questions such as what is the best treatment?, what side effects can occur? With a larger group, we can also show the expected course of some of the rarer forms of childhood IBD, such as oral Crohn?s disease, perianal-only Crohn?s disease, and ulcerative colitis of only the rectum, which have been poorly studied in childhood to date.

炎症性肠病(IBD)是儿童和青少年的常见问题，具有明显的尴尬症状，影响生长发育，干扰学校进步、家庭和社会生活。儿童IBD的治疗方法几乎没有成功的研究试验，所以我们从成人IBD的研究中得出结论，这些研究的问题可能是不同的。在整个苏格兰，许多儿童和青少年(超过450人)已经加入了我们对IBD病因(就遗传构成和环境中的触发因素而言)的研究。这个群体被称为队列，到目前为止，我们的研究在科学方面非常成功。尽管我们已经研究了所有可能在IBD病因中发挥作用的潜在重要基因，但没有一个被证明具有重要作用？负责的遗传原因还没有找到！我们正在增加队列中的苏格兰儿童和年轻人的数量，这将有助于识别更多潜在的遗传和环境原因。我们还希望进行治疗试验，以回答关键问题，如什么是最好的治疗方法？会发生什么副作用？在一个更大的群体中，我们也可以显示一些较罕见的儿童IBD的预期病程，例如口腔克罗恩？S病、仅限于肛周的克罗恩？S病和仅限于直肠的溃疡性结肠炎，这些在儿童时期迄今研究得很少。