Establishing the utility and molecular mechanisms of integrin alphav beta6-directed human-antibody therapy of cancer

癌症的侵袭能力要求它们的表面具有某些特定的分子，正是这种侵袭能力使癌症在体内扩散并最终杀死人。我们已经发现了一种新的入侵促进分子，叫做alphav beta6。它存在于许多不同类型的癌症表面，我们对死于这种疾病的患者的癌症组织进行的分析表明，癌症上存在的α v β 6可以显着缩短预期寿命。我们相信通过阻止alphav beta6发挥作用，我们可以减缓甚至阻止癌症的入侵，从而防止癌症如此迅速地杀死人类。在这项提议中，我们将使用我们专门的实验系统，测试抗体的能力，这些抗体旨在阻止alpha v beta6正常工作，实际上阻止癌症的生长和侵袭。我们希望我们的研究将使我们能够在不久的将来用这些抗体治疗癌症患者。我们的研究还将调查alphav beta6实际上是如何改变癌症的行为，使它们能够入侵的。这些信息将使我们能够在未来创造更好的癌症疗法。

The ability of cancers to invade requires that they have certain specialised molecules on their surface and it is this invasive ability that allows cancers to spread around the body and ultimately kill people. We have identified a new invasion-promoting molecule called alphav beta6. It is on the surface of many different types of cancer and our analysis of cancer tissues taken from patients who have died from the disease, show that the presence of alphav beta6 on cancers can significantly shorten life-expectancy. We believe by preventing alphav beta6 from working we can slow down or even stop cancers from invading and, therefore, from killing people so quickly. In this proposal, using our specialised experimental systems, we will test the ability of antibodies, designed to stop alphav beta6 from working properly, to actually prevent the growth and invasion of cancers. We expect that our studies will allow us to treat cancer patients with these antibodies in the near future. Our study will also investigate how the alphav beta6 actually changes the behaviour of cancers to enable them to invade. This information will allow us to create even better therapies for cancer in the future.