Effect of oestrogen on the serotonin system : role in the development of pulmonary hypertension

雌激素对血清素系统的影响：在肺动脉高压发展中的作用

• 批准号: G0801171/1
• 负责人: Margaret MacLean
• 金额: $ 25.48万
• 依托单位: University of Glasgow
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0801171%2F1
• 关键词: Effect; oestrogen; serotonin; system; role

Pulmonary hypertension occurs when the blood vessels of the lung close down. It is a fatal disease with patients dying within 3-5 years of diagnosis. It occurs more in females than males yet the reason for this is unknown. We have identified a possible reason for this. Serotonin is a chemical produced primarily by the gut but also by the lungs. It has a variety of effects including the ability to close down the blood vessels of the lungs. During pulmonary hypertension the activity of the serotonin system is increased. In mice models of pulmonary hypertension where the serotonin system is artificially increased, it is female mice that develop pulmonary hypertension. We wish to investigate if the female hormone oestrogen interacts with serotonin in such a way as to promote the development of pulmonary hypertension.

当肺血管关闭时，就会发生肺动脉高压。这是一种致命的疾病，患者在确诊后3-5年内死亡。它在女性中比男性更常见，但其原因尚不清楚。我们已经确定了造成这种情况的可能原因。5-羟色胺是一种化学物质，主要由肠道产生，但也由肺部产生。它有多种作用，包括关闭肺血管的能力。在肺动脉高压期间，5-羟色胺系统的活性增加。在人为增加5-羟色胺系统的肺动脉高压小鼠模型中，患上肺动脉高压的是雌性小鼠。我们希望研究女性激素雌激素是否与5-羟色胺相互作用，从而促进了肺动脉高压的发展。