Endogenous oestrogen is a key missing link in urethral hypospadias

内源性雌激素是尿道下裂的关键缺失环节

• 批准号: nhmrc : 1098480
• 负责人: A/Pr Andrew Pask
• 金额: $ 31.3万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/endogenous-oestrogen-key-urethral-hypospadias/662386
• 关键词: Endogenous; oestrogen; key; missing; link

Defects in penis development are among the most common birth abnormalities, and affect around 1 in every 150 live male births in Australia. Development of the penis is known to be driven by male hormones (androgens), but we have recently shown that oestrogen also plays a role in this process. This project will define the role of estrogen in penis development and how a loss or gain of estrogens can cause developmental defects.

阴茎发育缺陷是最常见的出生异常之一，在澳大利亚，每150名活着的男性新生儿中就有一名患有阴茎发育缺陷。众所周知，阴茎的发育是由男性激素(雄激素)驱动的，但我们最近表明，雌激素在这一过程中也起到了作用。这个项目将确定雌激素在阴茎发育中的作用，以及雌激素的损失或增加如何导致发育缺陷。