课题基金 / 基金详情

WOODCHUCK HEPATITIS VIRUS

WOODCHUCK HEPATITIS VIRUS
土拨鼠肝炎病毒
批准号：
3960540
负责人：
R H PURCELL
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3960540
关键词：
active immunization animal viral hepatitis antigen antibody reaction antiviral antibody cancer prevention chronic disease /disorder disease /disorder model duck hepatitis B virus hepatitis B antigens hepatitis vaccine hepatocellular carcinoma neoplasm /cancer immunotherapy newborn animals oncogenic virus serology /serodiagnosis virus infection mechanism virus related neoplasm /cancer

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中文摘要
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英文摘要
The woodchuck hepatitis virus (WHV) is taxonomically and serologically related to the hepatitis B virus (HBV). Infection with each of these viruses is associated with acute and chronic hepatitis and hepatic cell carcinoma in their respective hosts; these associations appear to be etiological in nature. The WHV/woodchuck model system provides a convenient means of studying the relationship between virus and host in the oncogenic process. Tests specific for the WHV antigen-antibody systems have been developed. Genetic relationships between the hepadnaviruses and retroviruses suggest a common origin. Genetically altered WHV genomes, constructed by recombinant DNA techniques are being studied in woodchucks in order to determine the biological significance of individual gene products.
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STUDIES OF ACQUIRED IMMUNE DEFICIENCY SYNDROME
SECOND AND THIRD-GENERATION HEPATITIS B VACCINES
SECOND AND THIRD-GENERATION HEPATITIS B VACCINES
DELTA AGENT