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A STUDY OF SPORADIC NEUROASTHENIA ASSOCIATED WITH EPSTEIN-BARR VIRUS

A STUDY OF SPORADIC NEUROASTHENIA ASSOCIATED WITH EPSTEIN-BARR VIRUS
与爱泼斯坦-巴尔病毒相关的散发性神经衰弱的研究
批准号：
3960634
负责人：
S E STRAUS
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3960634
关键词：
Epstein Barr virus Herpesviridae disease acyclovir antiviral agents chronic disease /disorder fatigue human subject human therapy evaluation human tissue microorganism disease chemotherapy mononucleosis placebos serology /serodiagnosis virus classification

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中文摘要
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英文摘要
The goal of this project is to characterize a chronic fatigue syndrome and to ascertain whether Epstein-Barr virus plays a role in its causation. We have identified and are further exploring a series of clinical and immunologic abnormalities in some patients. We have nearly completed a large placebo controlled trial of acyclovir therapy in 27 patients with unusual Epstein-Barr virus serologic profiles. Our desire is to determine whether chemotherapy alters symptoms, virus shedding rates or any of a series of immunologic abnormalities we have observed. Our planned studies in this area involve a heightened focus on individuals whose illness began with well documented acute infectious mononucleosis and on the molecular properties of virus recovered from them.
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