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CLINICAL AND BIOCHEMICAL STUDIES OF HUMAN ENTERAL ADENOVIRUS INFECTIONS

CLINICAL AND BIOCHEMICAL STUDIES OF HUMAN ENTERAL ADENOVIRUS INFECTIONS
人类肠道腺病毒感染的临床和生化研究
批准号：
4688385
负责人：
S E STRAUS
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/4688385
关键词：
AIDS Adenoviridae acute infectious nonbacterial gastroenteritis communicable disease diagnosis communicable diseases electron microscopy enzyme linked immunosorbent assay epidemiology fluorescence microscopy genetic manipulation genetic mapping human subject human tissue immunologic techniques messenger RNA microorganism culture microorganism immunology molecular cloning serology /serodiagnosis temperature sensitive mutant tissue /cell culture virus DNA virus RNA virus classification virus diseases virus genetics virus replication

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英文摘要
Enteroadenoviruses (EAds) comprise a serogroup with two related types of adenoviruses which are associated with gastroenteritis in infants. We have continued our studies of the molecular biology and epidemiology of EAds. We have completed a study using highly specific cloned EAd DNA fragments for rapid diagnosis of infection. Early events in the replication of EAds in permissive and nonpermissive cell lines are being studied by binding of radiolabeled virus particles to cells and by characterization of early mRNA synthesis by Northern hybridization analysis.
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