Nano-diffusion in the brain: mechanisms and implications examined with time-resolved fluorescence anisotropy imaging

大脑中的纳米扩散：通过时间分辨荧光各向异性成像检查的机制和影响

• 批准号: G0802216/1
• 负责人: Dmitri Rusakov
• 金额: $ 124.57万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0802216%2F1
• 关键词: Nano; diffusion; brain; mechanisms; implications

Rapid movements of signalling molecules underlie the functioning of neural circuitries at all levels of information handling in the brain, from individual cell-cell connections to cognitive activity, in health and disease. Our aim is to understand molecular mechanisms that control this relationship. To achieve this, we will adapt a recent technological breakthrough in physics allowing the monitoring of molecular mobility on the scale of nanoseconds. Results obtained with this novel methodology should ultimately unveil previously unknown targets for drug action.

在健康和疾病中，信号分子的快速运动是大脑中所有级别信息处理的神经电路功能的基础，从单个细胞-细胞连接到认知活动。我们的目标是了解控制这种关系的分子机制。为了实现这一目标，我们将采用物理学中最近的一项技术突破，允许在纳秒尺度上监测分子的流动性。用这种新的方法获得的结果最终应该会揭示以前未知的药物作用靶点。