Prospective study of bilingualism and cognitive reserve in the aging brain of Hispano adults with MCI

患有 MCI 的西班牙成年人衰老大脑中的双语和认知储备的前瞻性研究

• 批准号: 10584166
• 负责人: Stephen Coombes
• 金额: $ 61.6万
• 依托单位: FLORIDA ATLANTIC UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-15 至 2028-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10584166
• 关键词: Acculturation; Address; Adult; Age; Age Years; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Area; Biological; Brain; Cognition; Cognitive; Cohort Studies; Complex; Cultural Backgrounds; Data; Data Collection; Dementia; Diffusion Magnetic Resonance Imaging; Dissociation; Educational Background; Educational Status; Elderly; Ensure; Environmental Risk Factor; Ethnic Origin; Ethnic Population; Exhibits; Failure; Funding; Hippocampus; Hispanic; Hispanic Populations; Impaired cognition; Individual; Inferior; Inferior frontal gyrus; Intervention; Language; Learning; Longitudinal Studies; MRI Scans; Magnetic Resonance Imaging; Measures; Mediating; Medical center; Modification; Nerve Degeneration; Neuropsychology; Parietal Lobe; Population; Positioning Attribute; Prospective Studies; Prospective, cohort study; Psyche structure; Research; Research Personnel; Resistance; Risk; Role; Running; Semantics; Short-Term Memory; Statistical Models; Stress Tests; Structure; Testing; Time; Translating; United States National Institutes of Health; aging brain; amnestic mild cognitive impairment; bilingualism; brain volume; cognitive change; cognitive function; cognitive reserve; cohort; community engaged research; data sharing; design; entorhinal cortex; ethnic difference; indexing; innovation; insight; interest; longitudinal dataset; longitudinal design; mild cognitive impairment; multidisciplinary; multimodal neuroimaging; neural; neuroimaging; neuroprotection; outreach; prospective; recruit; resilience; response; social culture; sociocultural determinant; theories; white matter

Project Summary Estimates from the Alzheimer's Association indicate that approximately one in ten older adults in the US have Alzheimer's disease (AD) while 15 to 20% have mild cognitive impairment (MCI), projecting that about a third of those will develop dementia within five years. Several variables have been associated with delaying the onset and rate of cognitive decline in AD and have been grouped under the Cognitive Reserve/ Resilience (CR/R) theory; it postulates that complex mental activity throughout the lifetime creates resistance to cognitive decline despite the biological risk (brain loss). Emerging evidence shows that bilingualism may be one of these neuroprotective factors in the aging brain, but results in bilingualism and CR/R remain inconsistent. Our objective is to analyze the contribution of bilingualism to CR/R in a large cohort of aging Spanish/English bilinguals and Spanish monolinguals with amnestic MCI (aMCI). To overcome limitations in previous research, we will use a longitudinal design, operational characterization of bilingualism, refined sociocultural measures, and multimodal neuroimaging. The current study will leverage and extend a large ongoing NIH cohort prospective study from the 1Florida Alzheimer's Disease Research Center (1Florida ADRC), in which Spanish/English bilingual Hispanics with aMCI are well-represented (n = 120), but Spanish monolinguals are underrepresented although they comprise approximately 40% of foreign-born Hispanics in the US. In the present study, we directly address this by deploying an intensive, culturally-informed, community-engaged research approach in the Miami area to increase outreach and recruit 120 Hispanic monolinguals with aMCI. We will make the ADRC MCI bilingual and monolingual groups ethnically equivalent and create a longitudinal data set (n=240), ensuring that we are well-powered to determine the contribution of bilingualism to CR in the aMCI population. As co-investigators on the 1Florida ADRC, our research team is well-positioned to execute the proposed study. We will collect neuropsychological data at years 1, 2, and 3 and neuroimaging data (MRI and DTI) at years 1 and 3. The neuropsychological battery will include the Loewenstein-Acevedo Scale for Semantic Interference and Learning (LASSI-L), a cognitive stress test that evaluates failure to recover from Proactive Semantic Interference (frPSI) and is highly sensitive to subtle cognitive changes in early AD. The innovation lies in studying the relationship between brain diffusivity measures of WM and frPSI, as measured by the LASSI-L in combination with volumetric brain data; the use of Bilingual indexes of language proficiency and degrees of acculturation, and levels of education. Our findings will advance our understanding of the complex interactions between neural, environmental, and sociocultural factors and the role of bilingualism in CR/R in AD/ADRD, paving the way for new targets for interventions and providing fundamental insight into the role of language(s) in the aging brain.

项目摘要 阿尔茨海默氏症协会的估计表明，在美国，大约十分之一的老年人 阿尔茨海默氏病（AD），而15 - 20%有轻度认知障碍（MCI），预计约三分之一 这些人将在五年内患上痴呆症。有几个变量与推迟 AD中认知能力下降的发病率和发生率，并已被归类为认知储备/恢复力 (CR/R）理论;它假设一生中复杂的心理活动会对认知产生阻力。 尽管有生物风险（大脑丧失），但仍会下降。新出现的证据表明，双语可能是其中之一， 神经保护因素在老龄化的大脑，但结果双语和CR/R仍然不一致。我们 目的是分析双语对老年西班牙语/英语的大队列CR/R的贡献 双语者和西班牙单语者与遗忘MCI（aMCI）。为了克服以往研究的局限性， 我们将采用纵向设计，双语的操作特征，完善的社会文化措施， 和多模式神经成像。目前的研究将利用和扩展一个正在进行的大型NIH队列 佛罗里达阿尔茨海默病研究中心（1Florida ADRC）的一项前瞻性研究，其中 患有aMCI的西班牙语/英语双语西班牙裔患者有很好的代表性（n = 120），但西班牙语单语患者 尽管他们占美国外国出生的西班牙裔美国人的约40%，但他们的代表性不足。在 目前的研究，我们直接解决这一问题，部署一个密集的，文化知情，社区参与 研究方法在迈阿密地区，以增加外展和招募120名西班牙裔单语与aMCI。 我们将使ADRC MCI双语和单语群体在种族上等同，并建立纵向 数据集（n=240），确保我们有足够的能力来确定双语对CR的贡献， aMCI人群。作为1Florida ADRC的共同调查员，我们的研究团队能够很好地执行 建议的研究。我们将收集第1年、第2年和第3年的神经心理学数据和神经影像学数据（MRI 和DTI）。神经心理成套测验将包括Loewenstein-Acevedo量表， 语义干扰和学习（LASSI-L），一种认知压力测试，评估未能从 主动语义干扰（frPSI），对早期AD的微妙认知变化高度敏感。的 创新在于研究WM和frPSI的脑扩散率测量之间的关系，如测量的 采用LASSI-L结合脑体积数据，使用语言能力双语指数 文化适应程度和教育水平。我们的发现将促进我们对 神经，环境和社会文化因素之间的复杂相互作用以及双语在 在AD/ADRD中的CR/R，为新的干预目标铺平道路，并提供基本的见解， 语言在大脑老化中的作用。