Analysis of Physical Activity as an Environmental Risk Factor for Motor Neurone Disease (MND)

体力活动作为运动神经元疾病 (MND) 环境危险因素的分析

• 批准号: G0802332/1
• 负责人: Ceryl Moore
• 金额: $ 32.5万
• 依托单位: University of Sheffield
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0802332%2F1
• 关键词: Analysis; Physical; Activity; Environmental; Risk

In motor neurone disease (MND), damage to the nervous system causes progressive limb weakness and difficulty with speech, swallowing and ultimately breathing. The cause of MND is unknown and there are no effective treatments. Sadly, patients with MND usually die within 3 years of symptom onset. Interest in physical activity (PA) as a risk factor for MND arose from suggestions that professional sports people may develop MND more often than is expected. Therefore, we plan to perform a study to investigate if MND patients are more likely to have undertaken high levels of PA in the past compared to healthy volunteers. We propose to interview patients and volunteers using a questionnaire we have designed which measures the PA performed throughout a person‘s adult life. We will analyse the data collected to determine if an association does exist. We hypothesise that PA is a risk factor for MND in only a proportion of genetically susceptible individuals and by determining this association we will gain insight into this abnormal biological response to PA. We hope the results will ultimately contribute to the development of new MND treatments by improving our understanding of the environmental and genetic interacting factors associated with this disease.

在运动神经元疾病（MND）中，神经系统的损伤会导致进行性肢体无力、言语困难、吞咽困难，最终导致呼吸困难。MND的病因尚不清楚，也没有有效的治疗方法。令人遗憾的是，MND患者通常在症状出现后3年内死亡。人们对体育活动（PA）作为MND风险因素的兴趣源于职业运动员可能比预期更频繁地患上MND的建议。因此，我们计划进行一项研究，以调查与健康志愿者相比，MND患者是否更有可能在过去承担高水平的PA。我们建议使用我们设计的问卷来采访患者和志愿者，该问卷测量了一个人在整个成年生活中的PA表现。我们将分析收集到的数据，以确定是否存在关联。我们假设PA仅在一部分易感个体中是MND的危险因素，通过确定这种关联，我们将深入了解PA的异常生物学反应。我们希望通过提高我们对与这种疾病相关的环境和遗传相互作用因素的理解，这些结果最终将有助于开发新的MND治疗方法。