2-Methoxyestradiol analogues: prototype modulators of annexin II-dependent plasminogen activation

2-甲氧基雌二醇类似物：膜联蛋白 II 依赖性纤溶酶原激活的原型调节剂

• 批准号: nhmrc : 566776
• 负责人: A/Pr Richard Hughes
• 金额: $ 24.65万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/2-methoxyestradiol-analogues-plasminogen-activation/96549
• 关键词: Methoxyestradiol; analogues; prototype; modulators; annexin

The enzyme system that enables us to dissolve blood clots is similar to the system that enables cancer cells to escape from the primary tumour and travel in the blood to another organ to form a secondary cancer growth. We have new results showing that some drug candidates can distinguish between these two closely related enzyme systems. We are now working to develop inhibitors that will stop cancer cells from spreading without compromising the ability to dissolve blood clots.

使我们能够溶解血栓的酶系统类似于使癌细胞能够从原发肿瘤逃逸并在血液中移动到另一个器官以形成继发性癌症生长的系统。我们有新的结果表明，一些候选药物可以区分这两个密切相关的酶系统。我们现在正在努力开发一种抑制剂，可以在不影响溶解血栓的能力的情况下阻止癌细胞的扩散。