The structural basis of the interaction of insulin-like peptide 3, a key regulator of fertility, with its receptor.

胰岛素样肽 3（生育力的关键调节剂）与其受体相互作用的结构基础。

• 批准号: nhmrc : 509048
• 负责人: A/Pr Richard Hughes
• 金额: $ 37.05万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structural-basis-interaction-fertility-receptor/97107
• 关键词: structural; basis; interaction; insulin; like

The hormone, insulin-like peptide 3, has recently been shown to act directly on male and female germ cells to cause their maturation. It has considerable promise as a therapeutic agent for the regulation of fertility. Drugs based on the peptide may be used to assist in cases of infertility, and drugs that block its action have great potential as male and female contraceptives. Towards these goals, our project aims to understand how this peptide exerts its unique biological effects.

这种激素，胰岛素样肽3，最近被证明直接作用于男性和女性生殖细胞，使其成熟。它作为调节生育力的治疗剂具有相当大的前景。基于该肽的药物可用于辅助不孕症，阻断其作用的药物具有作为男性和女性避孕药的巨大潜力。为了实现这些目标，我们的项目旨在了解这种肽如何发挥其独特的生物学作用。