LOCAL AND SYSTEMIC REGULATION OF BONE DEVELOPMENT

本项目的目标是调查当地和系统的控制 骨骼发育的细胞外基质成分。 项目目前 研究内容包括：1）从人和哺乳动物中纯化骨诱导蛋白， 牛骨; 2）成骨素作用的特异性及其通过 其他生长因子; 3）转化生长因子和骨骼 胶原基质在骨诱导中的作用; 铝对基质诱导成骨过程中矿化影响 脱矿牙本质基质对牙本质发育的影响 肌肉向软骨的转变。

The objective of this project is to investigate local and systemic control of bone development by extracellular matrix components. Projects currently under study are: 1) purification of bone inductive proteins from human and bovine bone; 2) specificity of osteogenin action and its modulation by other growth factors; 3) transforming growth factors and bone differentiation; 4) role of collagenous substratum in bone induction; 5) influence of aluminum on mineralization during matrix-induced bone development, and 6) influence of demineralized dentin matrix on transformation of muscle into cartilage.