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LOCAL AND SYSTEMIC REGULATION OF BONE DEVELOPMENT

LOCAL AND SYSTEMIC REGULATION OF BONE DEVELOPMENT
骨骼发育的局部和全身调节
批准号：
4692609
负责人：
A H REDDI
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/4692609
关键词：
bone development bone marrow cartilage development cell differentiation chondrocytes crosslink developmental genetics estrogens extracellular matrix fibroblasts human tissue immunofluorescence technique monoclonal antibody normal ossification osteocytes physical chemical interaction proteoglycan skeletal pharmacology

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中文摘要
翻译
这个项目的目标是调查局部和系统的控制。 细胞外基质成分对骨骼发育的影响。实验性的 基质诱导骨发育模型是本研究的主要内容。 目前正在研究的项目有：1)提纯和表征 来自牛骨的骨诱导蛋白，2)抗牛骨诱导蛋白的单抗 骨诱导蛋白，3)基质诱导的骨折愈合潜能 骨，4)糖尿病骨基质对骨诱导的影响，5) 肌源性间充质细胞对骨诱导蛋白的趋化作用。
英文摘要
The objective of this project is to investigate local and systemic control of bone development by extracellular matrix components. The experimental model of matrix-induced bone development is the mainstay of this work. Projects currently under study are: 1) Purification and characterization of bone inductive proteins from bovine bone, 2) Monoclonal antibodies to bone inductive proteins, 3) The facture-healing potential of matrix-induced bone, 4) Influence of diabetic bone matrix on bone induction, and 5) Chemotaxis of muscle derived mesenchymal cells to bone inductive proteins.
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GROWTH AND DIFFERENTIATION FACTORS IN BONE AND CARTILAGE
GROWTH AND DIFFERENTIATION FACTORS IN BONE AND CARTILAGE
LOCAL AND SYSTEMIC REGULATION OF BONE DEVELOPMENT
GROWTH AND DIFFERENTIATION FACTORS IN BONE AND CARTILAGE
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