GROWTH AND DIFFERENTIATION FACTORS IN BONE AND CARTILAGE

该项目的目标是调查增长和 骨和软骨发育与修复中的分化因子。 特别强调骨发育中的启动因素。 成骨蛋白(骨形态发生蛋白-3)就是这种蛋白的原型 分化启动因子。目前正在进行的项目 调查的显著结果是：1)软骨表达 成骨细胞表型；2)鸡肢芽细胞的刺激 重组人骨诱导软骨分化及基质合成的研究 形态发生蛋白-2B；3)成骨蛋白对软骨细胞的影响；4) 胰岛素样生长因子II受体在软骨内的表达 骨分化；5)受体的化学鉴定 重组骨形态发生蛋白与成骨细胞的交联 细胞；6)成骨蛋白对单核细胞具有趋化作用；7)修复 灵长类动物的巨大头盖骨缺陷。 上述调查对纠正 骨科中的头面部和牙周缺陷与骨不连 做手术。

The objective of the project is to investigate the role of growth and differentiation factors in bone and cartilage development and repair. Special emphasis is placed on initiation factors in bone development. Osteogenin (Bone Morphogenetic Protein-3) is a prototype of such a differentiation initiation factor. The projects currently under investigation with salient findings are: 1) expression of cartilage phenotype by osteogenin; 2) stimulation of chick limb bud cell-induced cartilage differentiation and matrix synthesis by recombinant human Bone Morphogenetic Protein-2B; 3) influence of osteogenin on chondrocytes; 4) expression of insulin-like growth factor II receptor during endochondral bone differentiation; 5) identification of receptors by chemical crosslinking of recombinant bone morphogenetic protein to osteoblastic cells; 6) osteogenin is chemotactic for monocytes, and 7) repair of massive calvarial defects in primates. The above investigations have direct implications for correction of craniofacial and periodontal defects and non-unions in orthopaedic surgery.