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SYNTHESIS OF THYROXINE TRANSPORT PROTEINS

SYNTHESIS OF THYROXINE TRANSPORT PROTEINS
甲状腺素转运蛋白的合成
批准号：
3964789
负责人：
J ROBBINS
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3964789
关键词：
blood proteins density gradient ultracentrifugation drug adverse effect globulins human tissue liver cells messenger RNA peptides thyroxine analog tissue /cell culture

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中文摘要
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英文摘要
L-asparaginase (ASN), a drug used in the treatment of leukemia, has been reported to decrease specifically the serum thyroxine-binding globulin (TBG) levels. Studies with cultured human hepatoma cells revealed that ASN caused a dose dependent decrease of synthesis of both TBG and albumin, but the former was more sensitive to the drug. An additional effect on the survival of newly synthesized TBG was also observed.
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STUDIES OF THYROID DISEASES
SYNTHESIS OF THYROXINE TRANSPORT PROTEINS
THYROXINE PROTEIN INTERACTIONS
THYROID HORMONES-CELL INTERACTIONS
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