SYNTHESIS AND CHARACTERIZATION OF FORSKOLIN DERIVATIVES
SYNTHESIS AND CHARACTERIZATION OF FORSKOLIN DERIVATIVES
批准号:
3792429
负责人:
J ROBBINS
金额:
$0.0万
依托单位:
--
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
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至
中文摘要
二萜福斯克林已被证明能影响其他蛋白质
英文摘要
The diterpene forskolin has been demonstrated to affect proteins other
than adenylyl cyclase. However, there has been relatively little
information regarding the differences in the binding of forskolin at
functionally diverse proteins. Analogs of forskolin have been developed
which can be used to discriminate between adenylyl cyclase, the
facilitated glucose transporter, and the P-glycoprotein multidrug
transporter. The hydrogen binding requirements for forskolin
interactions at the glucose transporter and the adenylyl cyclase have
been determined and are very different. In addition, it has been shown
that the affinity of forskolin for the Glut-4 glucose transporter is
much higher than for the Glut-1 or Glut-3 transporter. However, the
hydrogen bonding characteristics for forskolin binding to the Glut-1,
Glut-3, and Glut-4 transporters are not very different. These data will
be useful in developing a model for the forskolin binding site at the
glucose transporter. Similar experiments are being carried out with
adenylyl cyclase subtypes. In addition, experiments are being carried
out to determine the structure activity relationships of forskolin for
interactions with the P-glycoprotein multidrug transporter.
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STUDIES OF THYROID DISEASES
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批准号:2342197
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J ROBBINS
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依托单位:
SYNTHESIS OF THYROXINE TRANSPORT PROTEINS
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批准号:4689989
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J ROBBINS
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依托单位:
THYROXINE PROTEIN INTERACTIONS
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批准号:3964783
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J ROBBINS
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依托单位:
THYROID HORMONES-CELL INTERACTIONS
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批准号:3918220
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J ROBBINS
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依托单位:
THYROID HORMONE INTERACTIONS WITH CELLS AND PROTEINS
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批准号:3754843
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J ROBBINS
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依托单位:
STUDIES IN THYROID DISEASE
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批准号:3876402
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J ROBBINS
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依托单位:
SYNTHESIS AND CHARACTERIZATION OF FORSKOLIN DERIVATIVES
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批准号:3804708
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J ROBBINS
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依托单位:--
STUDIES OF THYROID DISEASES
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批准号:6162014
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J ROBBINS
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依托单位:
THYROXINE PROTEIN INTERACTIONS
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批准号:3876401
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J ROBBINS
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依托单位:
THYROID HORMONES-CELL INTERACTIONS
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批准号:3855376
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J ROBBINS
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依托单位:
STUDIES IN THYROID DISEASE
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批准号:3855372
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J ROBBINS
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依托单位:
THYROID HORMONES-CELL INTERACTIONS
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批准号:3876406
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:J ROBBINS
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依托单位:
THYROID HORMONE INTERACTIONS WITH CELLS AND PROTEINS
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批准号:3840465
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J ROBBINS
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依托单位:
SYNTHESIS OF THYROXINE TRANSPORT PROTEINS
-
批准号:3964789
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项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:J ROBBINS
-
依托单位:
THYROID HORMONES-CELL INTERACTIONS
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批准号:4689990
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:J ROBBINS
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依托单位:
STUDIES OF THYROID DISEASES
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批准号:3776926
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:J ROBBINS
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依托单位:
SYNTHESIS OF THYROXINE TRANSPORT PROTEINS
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批准号:3855375
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项目类别:
-
资助金额:$0.0万
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财政年份:--
-
负责人:J ROBBINS
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依托单位:
THYROID HORMONE INTERACTIONS WITH CELLS AND PROTEINS
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批准号:3776925
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:J ROBBINS
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依托单位:
STUDIES OF THYROID DISEASES
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批准号:3840466
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:J ROBBINS
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依托单位:
STUDIES IN THYROID DISEASE
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批准号:3918217
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J ROBBINS
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依托单位:
海外基金