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THYROXINE PROTEIN INTERACTIONS

THYROXINE PROTEIN INTERACTIONS
甲状腺素蛋白相互作用
批准号：
3876401
负责人：
J ROBBINS
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3876401
关键词：
apolipoproteins binding proteins chemical binding conformation fibroblasts high density lipoproteins human tissue low density lipoprotein monoclonal antibody receptor receptor mediated endocytosis thyroid hormone binding protein thyroid hormones thyroxine triiodothyronine

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英文摘要
We previously demonstrated that high density lipoproteins (HDL) bind T4 in human plasma through a single binding site on apoA-I and that low density lipoproteins (LDL) bind T4 through 3 binding sites on apoB-100. By photoaffinity labeling with [(125)I]T4 and its inhibition by monoclonal antibodies to the apolipoproteins, we have investigated the location of the T4 binding sites. In apoA-I, the T4 site is in the N-terminal third of the molecule. In apoB-100, the T-4 sites are outside the LDL receptor binding domain and are located in the molecular domains designated as apoB-26, apoB-44 and apoB-30. Conformational changes due to interaction with lipids appear to result in altered patterns of monoclonal antibody inhibition.
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会议论文
STUDIES OF THYROID DISEASES
SYNTHESIS OF THYROXINE TRANSPORT PROTEINS
THYROXINE PROTEIN INTERACTIONS
THYROID HORMONES-CELL INTERACTIONS
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