DISPOSITION OF XENOBIOTICS

异生物质的处置

• 批准号: 3965185
• 负责人: L S BIRNBAUM
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3965185
• 关键词: drug administration routes; halobiphenyl /halotriphenyl compound; skin absorption; toxin metabolism

Pharmacokinetic factors can assist greatly in both dose-setting for toxicity studies and in interpretation of the results. Chemicals on-test by the NTP are nominated for disposition studies. The absorption (oral, dermal), distribution, metabolism, and excretion is studied in rats and other species as needed. The effect of dose is determined. In this way, the effects of chronic exposure may be predicted. The first chemicals to be studied in this project include o-benzyl-p-chlorophenol (BCP), and citral (oil of lemon). The dermal absorption of 4,4'-thiobis-(6-t-butyl-m-cresol) (TBBC) was also studied in rats and mice.

药代动力学因子可以极大地帮助剂量设定