DISPOSITION OF HALOGENATED DIBENZOFURANS

卤代二苯并呋喃的处置

• 批准号: 4693149
• 负责人: L S BIRNBAUM
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4693149
• 关键词: chemical structure function; dioxins; embryo /fetus toxicology; environmental toxicology; gastrointestinal toxin absorption; genetic strain; halobiphenyl /halotriphenyl compound; halogenation; isomer; polychlorodibenzofuran; toxicant screening; toxin metabolism

Halogenated dibenzofurans are found worldwide as environmental pollutants. Structurally related to other halogenated aromatic xenobiotics, their toxicity and disposition seem to vary with the degree and position of halogenation. This work has established that 2,3,7,8-tetrachlorodibenzofuran (TCDF), an extremely toxic isomer, is excreted only after metabolism and toxicity is inversely related to metabolic capability. The metabolites of TCDF produced by the rat are being characterized. There appear to be threshold body burden for toxicity. The distribution to the fetus was examined after maternal exposure. The role of body composition on the disposition of 2,3,7,8-tetrachlorodibenzodioxin (TCDD), the most toxic man-made compound known, is being examined in congenic mouse strains which are sensitive or resistant to TCDD toxicity. Absorption of octachlorodibenzo-p-dioxin (OCDD) from the gastrointestinal tract and the effect of dose on absorption is being studied in the rat.

卤代二苯并呋喃在世界范围内被发现是一种环境污染物质 污染物。 结构与其他卤代芳香族化合物相关 异生物质，其毒性和处置似乎随程度而变化 和卤化位置。 这项工作已经确定 2,3,7,8-四氯二苯并呋喃 (TCDF) 是一种剧毒异构体， 代谢后才排出体外，毒性与 代谢能力。 大鼠产生的 TCDF 代谢物为 被表征。 似乎存在阈值身体负担 毒性。 产后检查对胎儿的分布 接触。 身体成分对处置的作用 2,3,7,8-四氯二苯并二恶英 (TCDD)，毒性最强的人造化合物 已知，正在对敏感或敏感的同源小鼠品系进行检查 抗TCDD毒性。 八氯二苯并二恶英的吸收 （OCDD）来自胃肠道以及剂量对吸收的影响 正在老鼠身上进行研究。