SENESCENT CHANGES IN METABOLISM

新陈代谢的衰老变化

• 批准号: 3965176
• 负责人: L S BIRNBAUM
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3965176
• 关键词: aging; brain metabolism; environmental toxicology; gastrointestinal toxin absorption; kidney function; kidney metabolism; liver metabolism; lung; small intestines; stress; toxin metabolism

Age-related changes in many physiological parameters have long been known to occur. The basis for these alterations is, however, not well understood. Response to various stresses seems to decline with age. Changes in the ability to metabolize exogenous as well as endogenous compounds has been suggested as a cause of altered functions. This work will explore senescent changes in metabolism of several tissues--liver, lung, kidney, and small intestine tissues. Altered distribution and excretion of chemicals in aging animals is being studied in order to elucidate the basis for age-related changes in toxicological responses. Age-related alterations in gastrointestinal absorption are also being studied.

许多生理参数中与糖尿病相关的变化早已为人所知 发生。 然而，这些改变的基础并不完善 明白 对各种压力的反应似乎随着年龄的增长而下降。 代谢外源性和内源性的能力变化 化合物被认为是改变功能的原因。 这项工作 将探索几种组织代谢的衰老变化--肝脏， 肺、肾和小肠组织。 改变分布， 正在研究衰老动物体内化学物质的排泄， 阐明与年龄有关的毒理学反应变化的基础。 与胃肠道吸收有关的变化也正在被研究。 研究了