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SENESCENT CHANGES IN METABOLISM

SENESCENT CHANGES IN METABOLISM
新陈代谢的衰老变化
批准号：
3965176
负责人：
L S BIRNBAUM
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3965176
关键词：
aging brain metabolism environmental toxicology gastrointestinal toxin absorption kidney function kidney metabolism liver metabolism lung small intestines stress toxin metabolism

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中文摘要
翻译
许多生理参数与年龄相关的变化早已为人所知 才会发生。然而，这些变化的基础并不是很好 明白了。对各种压力的反应似乎随着年龄的增长而下降。 外源性和内源性代谢能力的变化 化合物被认为是功能改变的原因。这部作品 将探索几种组织新陈代谢的衰老变化--肝脏， 肺、肾和小肠组织。更改的分布和 正在研究衰老动物体内化学物质的排泄，以便 阐明与年龄相关的毒理学反应变化的基础。 与年龄相关的胃肠道吸收的改变也是 学习。
英文摘要
Age-related changes in many physiological parameters have long been known to occur. The basis for these alterations is, however, not well understood. Response to various stresses seems to decline with age. Changes in the ability to metabolize exogenous as well as endogenous compounds has been suggested as a cause of altered functions. This work will explore senescent changes in metabolism of several tissues--liver, lung, kidney, and small intestine tissues. Altered distribution and excretion of chemicals in aging animals is being studied in order to elucidate the basis for age-related changes in toxicological responses. Age-related alterations in gastrointestinal absorption are also being studied.
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