SENESCENT CHANGES IN METABOLISM

许多生理参数中与糖尿病相关的变化早已为人们所知 发生。 然而，这些改变的基础并不完善 明白 对各种压力的反应似乎随着年龄的增长而下降。 代谢外源性和内源性的能力变化 化合物被认为是改变功能的原因。 这项工作 将探索几种组织代谢的衰老变化--肝脏， 肺、肾、小肠、脑、淋巴组织。 酶系统 如葡糖醛酸转移酶、B-葡糖醛酸糖苷酶，以及参与 将研究中间代谢和免疫应答。 改变 正在研究化学物质在老龄动物体内的分布和排泄 为了阐明与年龄相关的毒理学变化的基础， 应答 胃肠道吸收中与胃蛋白酶相关的改变也是 被研究。

Age-related changes in many physiological parameters have long been known to occur. The basis for these alterations is, however, not well understood. Response to various stresses seems to decline with age. Changes in the ability to metabolize exogenous as well as endogenous compounds has been suggested as a cause of altered functions. This work will explore senescent changes in metabolism of several tissues--liver, lung, kidney, small intestine, brain, lymphoid tissues. Enzyme systems such as glucuronyl transferase, B-glucuronidase, and those involved in intermediary metabolism and immune responses will be investigated. Altered distribution and excretion of chemicals in aging animals is being studied in order to elucidate the basis for age-related changes in toxicological responses. Age-related alterations in gastrointestinal absorption are also being studied.