PROGRAM IN MACROMOLECULAR STRUCTURE, MOTION, CONTROL

该计划是针对高分子的结构研究， 蛋白质单晶体的分辨率数据 目前在核糖体和血浆等细胞器中可评估的几何形状 膜。 将采用的技术集中在衍射和解决方案 X射线和中子的散射。 除了时间平均值之外 结构，这是最直接的输出这样的工作，该计划将 特别是研究聚合物各部分的运动 链和亚基相对于彼此在较大的聚集体。 运动可以部分地从不同条件下的静态结构差异中推断出来。 环境条件和结扎。 特别令人感兴趣的是 聚合酶类酶在催化循环过程中的特定侧链 沿着核酸链，以及核糖体在核酸链上的移位步骤。 蛋白质合成过程中的信息。 这些过程的具体控制 将研究配体。 这些研究将结合联合收割机的实验和 这些问题的理论方法。

The program is directed at structural studies of macromolecules from high resolution data on proteins in the form of single crystals to the larger scale geometry presently assessable in organelles such as ribosomes and plasma membranes. The techniques to be employed center on diffraction and solution scattering of both X-rays and neutrons. In addition to the time-average structures, which are the most immediate output of such work, the program will be particularly aimed at studying the motion of various parts of the polymer chains and of subunits with respect to each other in the larger aggregates. Motion can, in part, be inferred from static structural differences under varied conditions of environment and ligation. Of special interest is the motion of specific side chains during catalytic cycles, of the polymerase class of enzymes along the nucleic acid chains, and the translocation step of ribosomes on the message during protein synthesis. The control of these processes by specific ligands will be investigated. The studies will combine both experimental and theoretical approaches to these problems.