Environmental modulation of the structure P. gingivalis surface macromolecules and effects on virulence.

牙龈卟啉单胞菌表面大分子结构的环境调节及其对毒力的影响。

• 批准号: G0900408/1
• 负责人: Mark Payne
• 金额: $ 29.79万
• 依托单位: Queen Mary University of London
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0900408%2F1
• 关键词: Environmental; modulation; structure; P.; gingivalis

Background Periodontitis is a chronic inflammatory disease of the structures that support the teeth. Disease progression leads to premature tooth loss and significant oral disfigurement and loss of ability to chew. Moderately severe disease affects 43% of the population. The disease is initiated by bacteria that form a complex colony (biofilm) on the tooth/gum interface and induce inflammation in a susceptible individual. Certain specific bacteria are associated with periodontitis, one common bacteria being called Porphyromonas gingivalis. This has the ability to change its outer structure depending on local conditions. It seems that in conditions of inflammation, increased temperature and higher concentration of blood products, the changes may offer the bacteria an increased ability to cause periodontitis.Nature of Proposed Research The aim of this study is to recreate this tooth/gum interface in an experimental model in which we can then further investigate the changes to the bacteria with different environmental conditions. It is then proposed to transfer these experimental conditions into an animal model to further investigate these interactions.Outcomes and Benefits Understanding these complex interactions between bacteria and individual will enable us to develop techniques for diagnosing and treating this common and debilitating disease.

背景牙周炎是一种支持牙齿结构的慢性炎症性疾病。疾病进展会导致牙齿过早脱落、口腔严重毁容和丧失咀嚼能力。中度严重疾病影响43%的人口。这种疾病是由细菌引起的，这些细菌在牙齿/牙床界面上形成一个复杂的菌落(生物膜)，并在易感个体中引起炎症。某些特定的细菌与牙周炎有关，其中一种常见的细菌被称为牙龈卟啉单胞菌。它有能力根据当地情况改变其外部结构。似乎在炎症、温度升高和血液制品浓度较高的条件下，这些变化可能会增加细菌引起牙周炎的能力。建议研究的性质本研究的目的是在一个实验模型中重建这种牙齿/牙床界面，然后我们可以在其中进一步研究不同环境条件下细菌的变化。然后，建议将这些实验条件转化为动物模型，以进一步研究这些相互作用。了解细菌和个体之间的这些复杂相互作用将使我们能够开发诊断和治疗这种常见且使人虚弱的疾病的技术。